Bile acids (BA) are water-soluble, amphipathic end products of the cholesterol catabolism which are synthesized in the liver, stored in the gall bladder and secreted in the intestine during digestion. Throughout this metabolism, BA change their form from primary to secondary and tertiary BA and their conjugates. Total bile acids (TBA) refer to the sum of all these forms. As part of the enterohepatic circulation, primary bile acids (BA) are secreted into the small intestine and reabsorbed by the terminal ileum (last section of the small intestine) after being involved in micelle formation. After reabsorption they are taken up by the liver over the portal venous blood. Under physiological conditions this process is very efficient, resulting in 95% reabsorption and recycling of secreted bile acids, resulting in a peripheral TBA blood level ≤ 10 μmol/L. The remaining 5% reach the colon, where they are metabolized by the gut microbiota (by bacterial deconjugation) and eliminated in the feces [1-14].